General
Preferred name
Lapaquistat
Synonyms
T-91485 ()
P&D ID
PD125855
CAS
189059-71-0
Tags
available
drug candidate
Drug Status
investigational
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Lapaquistat (T-91485), a cholesterol biosynthesis inhibitor, is the active metabolite of Lapaquistat acetate (HY-16274). Lapaquistat can decrease statin-induced myotoxicity in lipid-lowering therapy[1].
Compound Sets
3
DrugBank
DB16215
MedChem Express Bioactive Compound Library
HY-14925
ReFrame library
External IDs
15
Properties
(calculated by RDKit )
Molecular Weight
602.24
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
2
Rotatable Bonds
10
Ring Count
4
Aromatic Ring Count
2
cLogP
4.3
TPSA
125.84
Fraction CSP3
0.52
Chiral centers
2.0
Largest ring
7.0
QED
0.41
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
Drug Metabolite
Endogenous Metabolite
Pathway
Metabolic Enzyme/Protease
Source data