General
Preferred name
Otophylloside B
Synonyms
Qingyangshengenin B ()
P&D ID
PD125732
CAS
106758-54-7
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Otophylloside B, a C-21 steroidal glycoside isolated from Qingyangshen. Otophylloside B protects against A¦Â toxicity, which decreases A¦Â deposition by decreasing the expression of A¦Â at the mRNA level. Otophylloside B has antiepileptic activity[1][2][3].
DESCRIPTION Qingyangshengenin B (Otophylloside B) is a C-21 steroidal glycoside isolated from Qingyangshen. Qingyangshengenin B protects against Aβ toxicity, which decreases Aβ deposition by decreasing the expression of Aβ at the mRNA level. Qingyangshengenin B has antiepileptic and anti-aging effects, it can extend lifespan, increase heat stress-resistance, delay body paralysis, and increase the chemotaxis response in C. elegans models of Alzheimer's disease. Otophylloside B can suppress the seizure-like locomotor activity caused by pentylenetetrazole in zebrafish. (TargetMol Bioactive Compound Library)
Cell lines
5
Organisms
0
Compound Sets
2
MedChem Express Bioactive Compound Library
HY-N0582
TargetMol Bioactive Compound Library
TMS1461
External IDs
11
Properties
(calculated by RDKit )
Molecular Weight
922.53
Hydrogen Bond Acceptors
16
Hydrogen Bond Donors
4
Rotatable Bonds
13
Ring Count
7
Aromatic Ring Count
0
cLogP
4.59
TPSA
207.36
Fraction CSP3
0.88
Chiral centers
20.0
Largest ring
6.0
QED
0.11
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
Beta Amyloid
Amyloid-β
Amyloid-¦Â
Pathway
Neuronal Signaling
Neuroscience
Source data