General
Preferred name
HIRSUTINE
Synonyms
P&D ID
PD125691
CAS
7729-23-9
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Hirsutine, an indole alkaloid of Uncaria rhynchophylla, exhibits anti-cancer activity. Hirsutine induces apoptosis and is a potent Dengue virus inhibitor exhibiting low cytotoxicity[1][2][3].
PRICE 80
DESCRIPTION Hirsutine induces apoptosis and is a potent Dengue virus inhibitor exhibiting low cytotoxicity.Hirsutine has anticancer, cardioprotective, anti-hypertensive and anti-arrhythmic activities, it also has vasodilatation activity, the mechanism is related to blockade of Ca2+ influx through L-type Ca2+ channels and inhibition of intracellular Ca2+ release may have no relationship with K+ channels. (TargetMol Bioactive Compound Library)
Cell lines
0
Organisms
1
Compound Sets
4
Cayman Chemical Bioactives
36403
MedChem Express Bioactive Compound Library
HY-N2193
Selleckchem Bioactive Compound Library
hirsutine
TargetMol Bioactive Compound Library
TN1065
External IDs
15
Properties
(calculated by RDKit )
Molecular Weight
368.21
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
4
Ring Count
4
Aromatic Ring Count
2
cLogP
3.82
TPSA
54.56
Fraction CSP3
0.5
Chiral centers
3.0
Largest ring
6.0
QED
0.51
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
Apoptosis
Dengue virus
Flavivirus
Nitric oxide, Prostaglandin E2, Interleukin-1¦Â
Pathway
Anti-infection
Source data