General
Preferred name
Vicenin 2
Synonyms
Vicenin -2 ()
Vicenin-2 ()
P&D ID
PD125496
CAS
23666-13-9
Tags
available
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Vicenin 2, a flavonoid, is an orally active angiotensin-converting enzyme (ACE) inhibitor (IC50 of 43.83 ¦ÌM)[1]. Vicenin 2 has radioprotective, anti-nociceptive effects, anti-glycation anti-inflammatory, antioxidant, anticancer, antiangiogenic properties[2][3].
PRICE
231
DESCRIPTION
Vicenin 2 is an angiotensin-converting enzyme (ACE) inhibitor (IC50=43.83 ??M) from the aerial parts of Desmodium styracifolium. Vicenin 2 is an inhibitor of ??-glucosidase, PTP1B, and RLAR. Vicenin 2 has hepatoprotective, anti-cancer, antioxidant and anti-inflammatory activities, and DTL co-administration is more effective than either of the single agents in androgen-independent prostate cancer. Vicenin 2 might be a useful lead for the development of multiple target-oriented therapeutic modalities for the treatment of diabetes and diabetes-associated complications. Vicenin 2 could act as a UV light barrier to protect the plants.
DESCRIPTION
Vicenin 2 is an angiotensin-converting enzyme (ACE) inhibitor (IC50=43.83 μM) from the aerial parts of Desmodium styracifolium. Vicenin 2 is an inhibitor of α-glucosidase, PTP1B, and RLAR. Vicenin 2 has hepatoprotective, anti-cancer, antioxidant and anti-inflammatory activities, and DTL co-administration is more effective than either of the single agents in androgen-independent prostate cancer. Vicenin 2 might be a useful lead for the development of multiple target-oriented therapeutic modalities for the treatment of diabetes and diabetes-associated complications. Vicenin 2 could act as a UV light barrier to protect the plants.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
4
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
27
Molecular Weight
594.16
Hydrogen Bond Acceptors
15
Hydrogen Bond Donors
11
Rotatable Bonds
5
Ring Count
5
Aromatic Ring Count
3
cLogP
-2.39
TPSA
271.2
Fraction CSP3
0.44
Chiral centers
10.0
Largest ring
6.0
QED
0.15
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
ACE
Angiotensin-converting Enzyme (ACE)
ACE, STAT-3
Pathway
Metabolic Enzyme/Protease
Endocrinology/Hormones
Source data
