General
Preferred name
Nepetin
Synonyms
6-Methoxyluteolin ()
EUPAFOLIN ()
eupafolin, 6-methoxyluteolin ()
P&D ID
PD125429
CAS
520-11-6
Tags
available
drug candidate
Drug indication
Discovery agent
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Nepetin (6-Methoxyluteolin) is a natural flavonoid isolated from Eupatorium ballotaefolium HBK with potent anti-inflammatory activities. Nepetin inhibits IL-6, IL-8 and MCP-1 secretion with IC50 values of 4.43 ¦ÌM, 3.42 ¦ÌM and 4.17 ¦ÌM, respectively in ARPE-19 cells[1][2].
PRICE 189
DESCRIPTION Nepetin (6-Methoxyluteolin) has antioxidant activity, it is a potent inhibitor of histamine release and calcium influx via down-regulation of the Fc??RI ?? chain.
DESCRIPTION Nepetin (6-Methoxyluteolin) has antioxidant activity, it is a potent inhibitor of histamine release and calcium influx via down-regulation of the FcεRI α chain. (TargetMol Bioactive Compound Library)
Cell lines
1
Organisms
1
Compound Sets
5
Cayman Chemical Bioactives
40138
DrugMAP
DMLXKZH
MedChem Express Bioactive Compound Library
HY-N2572
Selleckchem Bioactive Compound Library
6-methoxyluteolin
TargetMol Bioactive Compound Library
TN1154
External IDs
23
Properties
(calculated by RDKit )
Molecular Weight
316.06
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
4
Rotatable Bonds
2
Ring Count
3
Aromatic Ring Count
3
cLogP
2.29
TPSA
120.36
Fraction CSP3
0.06
Chiral centers
0.0
Largest ring
6.0
QED
0.54
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Pathway
GPCR/G protein
Immunology/Inflammation
Membrane Transporter/Ion Channel
Metabolism
Neuroscience
Target
Interleukin Related
IL-6, IL-8 and MCP-1
Calcium Channel
Histamine Receptor
Source data