General
Preferred name
Gitogenin
Synonyms
P&D ID
PD125412
CAS
511-96-6
Tags
available
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
236
DESCRIPTION
1. Gitogenin, tigogenin, and solasodine are novel selective inhibitors of UGT1A4, and do not inhibit the activities of major human CYP isoforms. 2. Gitogenin and (25S)-5??-furastan-3??, 22, 26-triol are the inhibitors of enzyme ??-glucosidase with IC50 values of 37.2??0.18 and 33.5??0.22 uM, respectively.3. Gitogenin shows moderate stimulation of release activity on growth hormone from rat pituitary cells.
DESCRIPTION
1. Gitogenin, tigogenin, and solasodine are novel selective inhibitors of UGT1A4, and do not inhibit the activities of major human CYP isoforms. 2. Gitogenin and (25S)-5α-furastan-3β, 22, 26-triol are the inhibitors of enzyme α-glucosidase with IC50 values of 37.2±0.18 and 33.5±0.22 uM, respectively.3. Gitogenin shows moderate stimulation of release activity on growth hormone from rat pituitary cells.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
4
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
15
Molecular Weight
432.32
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
0
Ring Count
6
Aromatic Ring Count
0
cLogP
4.76
TPSA
58.92
Fraction CSP3
1.0
Chiral centers
13.0
Largest ring
6.0
QED
0.58
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Metabolism
Metabolic Enzyme/Protease
Target
Glycosidase
Transferase, Carbohydrate Metabolism
UGT1A4
Source data
