General
Preferred name
Hydroxy-α-sanshool
Synonyms
Hydroxy-α-sanshool ()
Hydroxy-?¦Á-?sanshool ()
Hydroxy-¦Á-sanshool ()
Hydroxy-??-sanshool ()
P&D ID
PD125130
CAS
83883-10-7
Tags
available
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Hydroxy-¦Á-sanshool is a transient receptor potential ankyrin 1 (TRPA1) and TRP vanilloid 1 (TRPV1) agonist with EC50s of 69 and 1.1 ¦ÌM, respectively. Hydroxy-¦Á-sanshool can be used for pain research[1][2].
PRICE
251
DESCRIPTION
Hydroxy-??-sanshool is an alkyl amide isolated from the pepper. It acts as a TRPA1 covalent and TRPV1 non-covalent agonist (EC50s: 69 and 1.1 ??M).
DESCRIPTION
Hydroxy-α-sanshool is an alkyl amide isolated from the pepper. It acts as a TRPA1 covalent and TRPV1 non-covalent agonist (EC50s: 69 and 1.1 μM).
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
3
MedChem Express Bioactive Compound Library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
15
Molecular Weight
263.19
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
2
Rotatable Bonds
8
Ring Count
0
Aromatic Ring Count
0
cLogP
2.9
TPSA
49.33
Fraction CSP3
0.44
Chiral centers
0.0
Largest ring
0.0
QED
0.4
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Endogenous Metabolite
TRP Channel
TRPA1
TRPV1
TRP Channel, Potassium Channel
Pathway
Membrane Transporter/Ion Channel
Metabolism
Metabolic Enzyme/Protease
Neuronal Signaling
Source data
