General
Preferred name
MEVIDALEN
Synonyms
LY3154207 ()
LY-3154207 ()
P&D ID
PD124803
CAS
1638667-79-4
Tags
available
drug candidate
Drug Status
investigational
Max Phase
2.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Mevidalen (LY3154207) is a potent, selective and orally active dopamine D1 receptor positive allosteric modulator (PAM) . The allosteric binding site of LY3154207 has been determined to reside at the intracellular loop 2 (ICL2) region of the receptor.
D1 PAMs are being developed to address the poor drug-like properties of selective orthosteric D1 agonists. In particular, LY3154207 does not induce tachyphylaxis in preclinical models, whereas orthosteric agonists do. LY3154207 exhibits pro-cognitive and motor-enhancing effects in vivo, and is being considered for potential utility in the treatment of neuropsychiatric disorders . (GtoPdb)
Compound Sets
4
ChEMBL Drugs
CHEMBL3421729
Guide to Pharmacology
10506
MedChem Express Bioactive Compound Library
HY-128770
ReFrame library
External IDs
15
Properties
(calculated by RDKit )
Molecular Weight
449.15
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
2
Rotatable Bonds
6
Ring Count
3
Aromatic Ring Count
2
cLogP
4.75
TPSA
60.77
Fraction CSP3
0.46
Chiral centers
2.0
Largest ring
6.0
QED
0.67
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Pathway
GPCR/G protein
Neuronal Signaling
Target
Dopamine Receptor
Source data