General
Preferred name
NF-56-EJ40
Synonyms
NF-56-EJ40 hydrochloride ()
2-(2-[4'-[(4-Methylpiperazin-1-yl)methyl]-[1,1'-biphenyl]-3-amido]phenyl)acetic acid dihydrochloride ()
P&D ID
PD124792
CAS
2380230-73-7
2728500-80-7
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION NF-56-EJ40 is a potent succinate receptor antagonist . (GtoPdb)
DESCRIPTION NF-56-EJ40 is a potent, high-affinity, and highly selective human SUCNR1 (GPR91) antagonist with an IC50 of 25 nM and a Ki of 33 nM, and shows almost no activity towards rat SUCNR1. NF-56-EJ40 has high affinity for humanized rat SUCNR1 with a Ki value of 17.4 nM[1].
PRICE 298
PRICE 76
DESCRIPTION NF-56-EJ40 is an effective and highly selective antagonist of human SUCNR1 with an IC50 of 25 nM and a Ki of 33 nM. (TargetMol Bioactive Compound Library)
DESCRIPTION An antagonist of succinate receptor. (Enamine Bioactive Compounds)
DESCRIPTION NF-56-EJ40 hydrochloride is a potent, high-affinity, and highly selective human SUCNR1 (GPR91) antagonist with an IC50 of 25 nM and a Ki of 33 nM, and shows almost no activity towards rat SUCNR1. NF-56-EJ40 hydrochloride has high affinity for humanized rat SUCNR1 with a Ki value of 17.4 nM. (TargetMol Bioactive Compound Library)
Compound Sets
9
Axon Medchem Screening Library
3056
Concise Guide to Pharmacology 2021/22
10519
Concise Guide to Pharmacology 2023/24
10519
Enamine Bioactive Compounds
EBC-267064
EUbOPEN Chemogenomics Library
EUB0002413
Guide to Pharmacology
10519
MedChem Express Bioactive Compound Library
HY-130246
Selleckchem Bioactive Compound Library
nf-56-ej40
TargetMol Bioactive Compound Library
T12216
T12216L
External IDs
12
Properties
(calculated by RDKit )
Molecular Weight
443.22
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
7
Ring Count
4
Aromatic Ring Count
3
cLogP
3.98
TPSA
72.88
Fraction CSP3
0.26
Chiral centers
0.0
Largest ring
6.0
QED
0.58
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
HGPR91
SUCNR1
SUCNR1 antagonist
Succinate Receptor 1
GPR
Pathway
GPCR/G protein
Endocrinology/Hormones
Recommended Cell Concentration
None
Source data