General
Preferred name
PD124414
Synonyms
1-(pyridin-2-yl)piperazine ()
1-(2-Pyridyl)piperazine ()
P&D ID
PD124414
CAS
34803-66-2
Tags
available
drug candidate
Drug indication
Discovery agent
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
29
DESCRIPTION
1-(2-Pyridyl)piperazine (NSC-13778) is a selective ??2-adrenoceptor antagonists. 1-(2-Pyridyl)piperazine shows sympatholytic activity. 1-(2-Pyridyl)piperazine is also a metabolite of Azaperone.
DESCRIPTION
An antagonist of alpha2-adrenergic receptor with Ki= 37nM.
(Enamine Bioactive Compounds)
DESCRIPTION
Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex using [3H]clonidine as the radioligand
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
3
DrugMAP
Enamine Bioactive Compounds
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
17
Molecular Weight
163.11
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
1
Ring Count
2
Aromatic Ring Count
1
cLogP
0.49
TPSA
28.16
Fraction CSP3
0.44
Chiral centers
0.0
Largest ring
6.0
QED
0.65
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
¦Á2-adrenoceptor
MOA
Adrenergic Receptor
Source data
