General
Preferred name
Licochalcone B
Synonyms
P&D ID
PD124273
CAS
58749-23-8
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Licochalcone B is an extract from the root of Glycyrrhiza uralensis. Licochalcone B inhibits amyloid ¦Â (42) self-aggregation (IC50=2.16 ¦ÌM) and disaggregate pre-formed A¦Â42 fibrils, reduce metal-induced A¦Â42 aggregation through chelating metal ionsLicochalcone B inhibits phosphorylation of NF-¦ÊB p65 in LPS signaling pathway. Licochalcone B inhibits growth and induces apoptosis of NSCLC cells. Licochalcone B specifically inhibits the NLRP3 inflammasome by disrupting NEK7©\NLRP3 interaction[1][2][3][4].
PRICE 130
DESCRIPTION 1. Licochalcone B (LCB) inhibits the proliferation of human malignant bladder cancer cell lines (T24 and EJ) in vitro and antitumor activity in vivo in MB49 (murine bladder cancer cell line) tumor model. 2. LCB and Licochalcone D(LCD) significantly reduced the LPS-induced production of NO, TNFalpha and MCP-1. 3. A novel LCB derivative compound: (E)-3-(3, 4-dihydroxy-2-methoxyphenyl)-1-(2, 4-dihydroxyphenyl)prop-2-en-1-one inhibits inflammatory reactions in macrophages and protects mice from endotoxin shock. (TargetMol Bioactive Compound Library)
Cell lines
1
Organisms
0
Compound Sets
2
MedChem Express Bioactive Compound Library
HY-N0373
TargetMol Bioactive Compound Library
T4S0350
External IDs
18
Properties
(calculated by RDKit )
Molecular Weight
286.08
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
3
Rotatable Bonds
4
Ring Count
2
Aromatic Ring Count
2
cLogP
2.71
TPSA
86.99
Fraction CSP3
0.06
Chiral centers
0.0
Largest ring
6.0
QED
0.46
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Amyloid-β
Amyloid-¦Â
Apoptosis
NOD-like Receptor (NLR)
Pathway
Immunology/Inflammation
Neuronal Signaling
Neuroscience
Source data