General
Preferred name
Robinin
Synonyms
NSC 9222 ()
P&D ID
PD124215
CAS
301-19-9
81992-85-0
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Robinin is a flavonoid that can be extracted from the leaves of purple cowpea, inhibiting TGF-¦Â, TLR4/NF-¦ÊB and TLR2-PI3k-AKT signaling pathways. Robinin exerts anti-inflammatory and anti-tumor effects. The combination of Robinin and Methotrexate (HY-14519) reduces inflammation in experimental arthritis, Robinin can decrease the Doxorubicin (HY-15142A) induced cardiac toxicity effect[1][2][3][4].
PRICE 292
DESCRIPTION Flavone glycoside from Robinia with antibacterial and diuretic properties; derived from kaempferol.The ability of robinin to reverse the multidrug resistance of the human colon cancer cell line Colo 320 expre??ing MDR1/LRP was explored by monitoring their uptake of Rhodamine 123, but was shown to have minimal effect. Robinin (NSC-9222) was detected in lysates of the human breast cancer cell line MCF-7 using liquid chromatography-tandem ma?? spectrometry.
DESCRIPTION Flavone glycoside from Robinia with antibacterial and diuretic properties; derived from kaempferol.The ability of robinin to reverse the multidrug resistance of the human colon cancer cell line Colo 320 expreβing MDR1/LRP was explored by monitoring their uptake of Rhodamine 123, but was shown to have minimal effect. Robinin (NSC-9222) was detected in lysates of the human breast cancer cell line MCF-7 using liquid chromatography-tandem maβ spectrometry. (TargetMol Bioactive Compound Library)
Compound Sets
2
MedChem Express Bioactive Compound Library
HY-N1346
TargetMol Bioactive Compound Library
T2S0265
External IDs
32
Properties
(calculated by RDKit )
Molecular Weight
740.22
Hydrogen Bond Acceptors
19
Hydrogen Bond Donors
11
Rotatable Bonds
8
Ring Count
6
Aromatic Ring Count
3
cLogP
-2.89
TPSA
308.12
Fraction CSP3
0.55
Chiral centers
15.0
Largest ring
6.0
QED
0.11
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
TLR
Apoptosis
Toll-like Receptor (TLR)
Pathway
Immunology/Inflammation
Source data