General
Preferred name
Phallodendrin
Synonyms
Phellodendrine (chloride) ()
Phellodendrine ()
Phellodendrine (chloride) ()
P&D ID
PD124201
CAS
6873-13-8
104112-82-5
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE 55
DESCRIPTION Phellodendrine chloride is a plant alkaloid found in Phellodendron amurense. Phellodendrine chloride suppresses the proliferation of KRAS mutated pancreatic cancer cells through inhibition of nutrients uptake via macropinocytosis [1]. Phellodendrine chloride promotes autophagy by regulating the AMPK/mTOR pathway and reduce the intestinal damage of ulcerative colitis[2].
DESCRIPTION 1. Phellodendrine (Phallodendrin) has anti-nephritic activity, may be due to its ability to inhibit the proliferation or the migration of macrophages and cytotoxic T lymphocytes in the glomeruli. (TargetMol Bioactive Compound Library)
Compound Sets
3
Cayman Chemical Bioactives
34802
MedChem Express Bioactive Compound Library
HY-N0735
TargetMol Bioactive Compound Library
T6S0781
External IDs
19
Properties
(calculated by RDKit )
Molecular Weight
342.17
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
2
Ring Count
4
Aromatic Ring Count
2
cLogP
2.92
TPSA
58.92
Fraction CSP3
0.4
Chiral centers
2.0
Largest ring
6.0
QED
0.82
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Akt
NF-κB
NF-¦ÊB
AMPK
Apoptosis
Autophagy
COX
Interleukin Related
MMP
MTOR
p38 MAPK
PI3K
PKC
Reactive Oxygen Species (ROS)
STAT
Pathway
Cytoskeletal Signaling
PI3K/Akt/mTOR signaling
Epigenetics
Immunology/Inflammation
JAK/STAT Signaling
MAPK/ERK Pathway
Metabolic Enzyme/Protease
PI3K/Akt/mTOR
Stem Cell/Wnt
TGF-beta/Smad
Source data