General
Preferred name
MSD-M1PAM
Synonyms
PQCA ()
P&D ID
PD122454
CAS
1144504-35-7
Tags
available
free of charge
probe
Probe info
Probe type
experimental probe
Probe sources
Chemical Probes.org
High-quality chemical probes
Open Science Probes
Probe targets
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION PQCA is a highly selective and potent muscarinic M1 receptor positive allosteric modulator. PQCA has an EC50 value of 49 nM and 135 nM on rhesus and human M1 receptor, respectively. PQCA is inactive for other muscarinic receptors. PQCA has potential to reduce the cognitive deficits associated with Alzheimer's disease[1][2].
PRICE 164
MOA Modulator (Chemical Probes.org)
DESCRIPTION PQCA is a muscarinic M1 receptor-positive allosteric regulator, which is highly selective and effective. PQCA exhibited EC50 values of 49 nM in rhesus monkey and 135 nM in human M1 receptors, but showed no activity against other muscarinic receptors. PQCA is a potential compound for reducing cognitive deficits associated with Alzheimer's disease. (TargetMol Bioactive Compound Library)
Compound Sets
8
Cayman Chemical Bioactives
41358
Chemical Probes.org
msd-m1pam
CZ-OPENSCREEN Bioactive Library
EUbOPEN Chemogenomics Library
EUB0000252
High-quality chemical probes
PD122454
MedChem Express Bioactive Compound Library
HY-118342
Open Science Probes
MSD-M1PAM
TargetMol Bioactive Compound Library
T12531
External IDs
10
Properties
(calculated by RDKit )
Molecular Weight
388.15
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
1
Rotatable Bonds
4
Ring Count
4
Aromatic Ring Count
3
cLogP
2.45
TPSA
98.7
Fraction CSP3
0.27
Chiral centers
0.0
Largest ring
6.0
QED
0.74
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
mAChR
CHRM1
MOA
Positive allosteric modulator
Pathway
Neuroscience
GPCR/G protein
Neuronal Signaling
Control name
MSD-M1PAM-NC
Target class
GPCR
Target subclass
Acetylcholine Receptor
Recommended Cell Concentration
1 uM
Source data