General
Preferred name
LIAFENSINE
Synonyms
BMS820836 ()
BMS 820836 ()
DB104 ()
BMS-820836 ()
Liafensina ()
P&D ID
PD122145
CAS
1198790-53-2
Tags
available
drug candidate
Drug Status
investigational
Max Phase
2.0
Drug indication
depressive disorder
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
1079
DESCRIPTION
This active molecular is a SNDR (serotonin-norepinephrine-dopamine reuptake) inhibitor It was originated by Bristol-Myers Squibb for the treatment of major depressive disorder. In Feb 2013, Phase-II clinical trials in Major depressive disorder (treatment-experienced) in Argentina was on going. In May 2013, Bristol-Myers Squibb completed a phase II trial in Argentina, Australia, Austria, Canada, France, India, Italy, Puerto Rico, South Africa, Spain, United Kingdom and USA. In Oct 2013, Bristol-Myers Squibb discontinued a phase II trial in Major depressive disorder (treatment resistant) because of its increased capacity for side effects as well as potential for abuse.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Liafensine(BMS-820836) is a novel and selective triple monoamine reuptake inhibitor with inhibitory effects on the reuptake of serotonin, norepinephrine, and dopamine for the study of major depressive disorder and central nervous system disorders.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
4
BOC Sciences Bioactive Compounds
ChEMBL Drugs
DrugBank
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
17
Molecular Weight
366.18
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
2
Ring Count
5
Aromatic Ring Count
4
cLogP
4.46
TPSA
55.04
Fraction CSP3
0.17
Chiral centers
1.0
Largest ring
6.0
QED
0.57
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
GPCR/G protein
Neuroscience
Solubility
Soluble in DMSO
Target
serotonin reuptake
norepinephrine reuptake
dopamine reuptake
Source data
