General
Preferred name
Obicetrapib
Synonyms
TA8995 ()
AMG899 ()
Obicetrapib (free base) ()
AMG 899 ()
AMG-899 ()
TA-8995 ()
DEZ-001 ()
OBICETRAPIB CALCIUM ()
CASA ()
TA-8995 CALCIUM ()
P&D ID
PD122138
CAS
866399-87-3
Tags
available
drug candidate
Drug indication
Disorder of lipid metabolism
Hyperlipidaemia
Cardiovascular disease
Abnormal circulating lipid concentration
Drug Status
investigational
Max Phase
1.0
3.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Obicetrapib is a clinical lead, orally bioavailable, small molecule, cholesterol ester transfer protein (CETP; P11597) inhibitor . It was developed as a treament for dyslipidemia. Agents of the CETP inhibitor class are proposed to increase HDL cholesterol, lower LDL cholesterol, and enhance reverse cholesterol transport, as a mechanism to reduce the risks of elevated cholesterol on atherosclerosis. Prior to the re-launching of trials involving obicetrapib by NewAmsterdam Pharma, no CETP inhibitor had demonstrated sufficient safety and/or efficacy in a clinical study to warrant continued development . (GtoPdb)
DESCRIPTION TA-8995 is a new and selective cholesteryl ester transfer protein (CETP) inhibitor.
PRICE 673
DESCRIPTION Obicetrapib (AMG-899) is an inhibitor of cholesteryl ester transfer protein. (TargetMol Bioactive Compound Library)
Compound Sets
7
ChEMBL Drugs
CHEMBL3785197
CHEMBL6068417
DrugBank
DB14890
DrugMAP
DMAZHT0
Guide to Pharmacology
12205
MedChem Express Bioactive Compound Library
HY-18778
ReFrame library
TargetMol Bioactive Compound Library
T28225
External IDs
18
Properties
(calculated by RDKit )
Molecular Weight
722.22
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
1
Rotatable Bonds
11
Ring Count
4
Aromatic Ring Count
3
cLogP
8.67
TPSA
105.09
Fraction CSP3
0.44
Chiral centers
2.0
Largest ring
6.0
QED
0.15
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
CETP
Pathway
Metabolism
Metabolic Enzyme/Protease
Source data