General
Preferred name
Tavapadon
Synonyms
PF-6649751 ()
CVL-751 ()
(Rac)-Tavapadon ()
PF-06649751 ()
(Rac)-PF-06649751 ()
(Rac)-CVL-751 ()
P&D ID
PD122133
CAS
1643489-24-0
1643462-64-9
Tags
available
drug candidate
Drug Status
investigational
Max Phase
3.0
Drug indication
Liver disease
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION (Rac)-Tavapadon ((Rac)-PF-06649751) is a potent and selective noncatechol dopamine D1 receptor agonist. (Rac)-Tavapadon displays potent full agonism in the GS activation assay as well as partial agonism in the ¦Â-arrestin2 recruitment assay (GS-cAMP, EC50=0.8 nM; ¦Â-arrestin2, EC50=68 nM). (Rac)-Tavapadon has antiparkinsonian activity[1].
PRICE 240
DESCRIPTION Tavapadon (CVL-751) is an orally bioavailable, brain-penetrant, non-catechol dopamine D1/D5 receptor partial agonist . (GtoPdb)
DESCRIPTION Tavapadon (CVL-751) is an orally active and highly selective dopamine D1/D5 receptor partial agonist. (TargetMol Bioactive Compound Library)
Compound Sets
7
Cayman Chemical Bioactives
33556
ChEMBL Drugs
CHEMBL3697617
DrugBank
DB14899
Guide to Pharmacology
13372
MedChem Express Bioactive Compound Library
HY-119486A
HY-119486
ReFrame library
TargetMol Bioactive Compound Library
T16999
External IDs
16
Properties
(calculated by RDKit )
Molecular Weight
391.11
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
1
Rotatable Bonds
3
Ring Count
3
Aromatic Ring Count
3
cLogP
3.56
TPSA
76.98
Fraction CSP3
0.21
Chiral centers
0.0
Largest ring
6.0
QED
0.74
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
Dopamine Receptor
Arrestin
D1
D5
dopamine
Pathway
GPCR/G protein
Neuronal Signaling
Neuroscience
Source data