General
Preferred name
PCO-371
Synonyms
2,4-Imidazolidinedione, 1-(3,5-dimethyl-4-(2-((4-oxo-2-(4-(trifluoromethoxy)phenyl)-1,3,8-triazaspiro(4.5)dec-1-en-8-yl)sulfonyl)ethyl)phenyl)-5,5-dimethyl- ()
PCO371 ()
Pc-0371 ()
P&D ID
PD122098
CAS
1613373-33-3
Tags
available
drug candidate
Drug indication
Hypoparathyroidism
Drug Status
investigational
Max Phase
1.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
PCO371 is an orally active full agonist of parathyroid hormone receptor 1 (PTHR1), with no effect on PTH type 2 receptor.
PRICE
444
DESCRIPTION
PCO371 is an orally avaialble non-peptide parathyroid hormone receptor 1 (PTH1R) biased agonist and was considered as a potential hypoparathyroidism treatment. This small molecule binds within the receptor intracellular cavity and stabilises the receptor-Gs interaction, thus biasing activation towards G protein signalling over β-arrestin recruitment .
(GtoPdb)
DESCRIPTION
PCO371 is a selective PTHR1 agonist that can be used to treat hypoparathyroidism.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
PCO371 (2,4-Imidazolidinedione, 1-(3,5-dimethyl-4-(2-((4-oxo-2-(4-(trifluoromethoxy)phenyl)-1,3,8-triazaspiro(4.5)dec-1-en-8-yl)sulfonyl)ethyl)phenyl)-5,5-dimethyl-) is an orally active full agonist of parathyroid hormone receptor 1. It has no effect on PTH type 2 receptor.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
9
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
ChEMBL Drugs
DrugBank
DrugMAP
Guide to Pharmacology
MedChem Express Bioactive Compound Library
ReFrame library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
16
Molecular Weight
635.2
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
2
Rotatable Bonds
7
Ring Count
5
Aromatic Ring Count
2
cLogP
3.32
TPSA
137.48
Fraction CSP3
0.45
Chiral centers
0.0
Largest ring
6.0
QED
0.45
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
THR
thyroid hormone receptor-1 (PTHR1)
PTHR
Pathway
GPCR/G protein
Endocrinology/Hormones
Solubility
Soluble in DMSO
Source data
