General
Preferred name
VAROGLUTAMSTAT
Synonyms
PQ-912 ()
Pq912 ()
P&D ID
PD120282
CAS
1276021-65-8
Tags
available
drug candidate
Drug indication
Dementia
Drug Status
investigational
Max Phase
2.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Varoglutamstat (PQ912) is a glutaminyl cyclase inhibitor . It inhibits post-translational pyroglutamyl modification at the N-terminal of substrate proteins. This modification has been identified as contributing to the neurotoxicity of amyloid-β peptides deposited in Alzheimer's disease, making glutaminyl cyclase inhibitors of therapeutic interest for disease-modifying potential .
(GtoPdb)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
3
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
16
Molecular Weight
336.16
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
2
Rotatable Bonds
5
Ring Count
4
Aromatic Ring Count
3
cLogP
3.62
TPSA
70.25
Fraction CSP3
0.26
Chiral centers
1.0
Largest ring
6.0
QED
0.75
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Amyloid-¦Â
Pathway
Neuronal Signaling
Source data
