General
Preferred name
GSK840
Synonyms
GSK'840 ()
P&D ID
PD120213
CAS
2361146-30-5
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION GSK840 (GSK'840) is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, which binds RIP3 kinase domain with an IC50 of 0.9 nM, and inhibits kinase activity with an IC50 of 0.3 nM[1].
PRICE 93
DESCRIPTION GSK840 (GSK'840) is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor that binds to the RIP3 kinase domain (IC50: 0.9 nM) and inhibits kinase activity (IC50: 0.3 nM). (TargetMol Bioactive Compound Library)
Compound Sets
6
Cayman Chemical Bioactives
35661
Chemical proteomics reveals the target landscape of 1,000 kinase inhibitors
EUbOPEN Chemogenomics Library
EUB0001243
Kinase Chemogenomic Set (KCGS)
GSK840
MedChem Express Bioactive Compound Library
HY-104021
TargetMol Bioactive Compound Library
T11501
External IDs
6
Properties
(calculated by RDKit )
Molecular Weight
365.17
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
1
Rotatable Bonds
4
Ring Count
3
Aromatic Ring Count
3
cLogP
3.27
TPSA
73.22
Fraction CSP3
0.29
Chiral centers
0.0
Largest ring
6.0
QED
0.72
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Pathway
Apoptosis
NF-κB
Target
RIPK3
RIP Kinase
RIP3
Recommended Cell Concentration
1 uM
Source data