General
Preferred name
A1874
Synonyms
P&D ID
PD120130
CAS
2064292-12-0
Tags
available
PROTAC
probe
Probe info
Probe type
experimental probe
Probe sources
Chemical Probes.org
High-quality chemical probes
Probe targets
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
MOA Degrader (PROTAC) (Chemical Probes.org)
DESCRIPTION A1874 is a nutlin-based and BRD4-degrading PROTAC which induces BRD4 degradation in cells. Effective in inhibiting many cancer cell lines proliferation. (TargetMol Bioactive Compound Library)
Compound Sets
7
Cayman Chemical Bioactives
40842
Chemical Probes.org
a1874
High-quality chemical probes
PD120130
MedChem Express Bioactive Compound Library
HY-114305
PROTAC-DB
208
Selleckchem Bioactive Compound Library
a1874
TargetMol Bioactive Compound Library
T5442
External IDs
7
Properties
(calculated by RDKit )
Molecular Weight
1171.35
Hydrogen Bond Acceptors
14
Hydrogen Bond Donors
4
Rotatable Bonds
22
Ring Count
8
Aromatic Ring Count
6
cLogP
10.34
TPSA
203.11
Fraction CSP3
0.4
Chiral centers
5.0
Largest ring
7.0
QED
0.05
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
BRD4
Epigenetic Reader Domain
PROTACs
Epigenetic Reader Domain,PROTAC
Pathway
Chromatin/Epigenetic
Epigenetics
Target class
Epigenetic
Target subclass
Bromodomain
Control
canSAR3549010
Source data