General
Preferred name
GSK843
Synonyms
GSK-843 ()
GSK'843 ()
P&D ID
PD120107
CAS
1601496-05-2
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION GSK-843 (GSK'843) is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, which binds RIP3 kinase domain with an IC50 of 8.6 nM, and inhibits kinase activity with an IC50 of 6.5 nM. GSK-843 can be used for the research of inflammation[1][2].
PRICE 32
DESCRIPTION GSK-843 (GSK'843) is a selective and potent RIP3 inhibitor with an IC50 value of 8.6 nM for the structural domain of RIP3 kinase. It has potential analgesic activity, inhibits the expression of RIP3 and NLRP3 in the SDH of CFA mice, and can be used as adjunctive therapy for treating inflammation.
Compound Sets
5
Cayman Chemical Bioactives
39835
Chemical proteomics reveals the target landscape of 1,000 kinase inhibitors
EUbOPEN Chemogenomics Library
EUB0001875
Kinase Chemogenomic Set (KCGS)
GSK843
MedChem Express Bioactive Compound Library
HY-125402
External IDs
9
Properties
(calculated by RDKit )
Molecular Weight
377.08
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
1
Rotatable Bonds
2
Ring Count
5
Aromatic Ring Count
5
cLogP
4.86
TPSA
69.62
Fraction CSP3
0.11
Chiral centers
0.0
Largest ring
6.0
QED
0.48
QED
0.48
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
RIPK3
Apoptosis
RIP Kinase
Recommended Cell Concentration
1 uM
Source data