General
Preferred name
N-trans-Feruloyltyramine
Synonyms
Moupinamide ()
N-Feruloyltyramine ()
N-TRANS-FERULOYL TYRAMINE ()
P&D ID
PD119931
CAS
65646-26-6
66648-43-9
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION N-trans-Feruloyltyramine (N-feruloyltyramine), an alkaloid, is a potent antioxidant. N-trans-Feruloyltyramine improves H2O2-induced intracellular ROS generation and decreases apoptosis. N-trans-Feruloyltyramine has the potential for oxidative stress-related neurodegenerative conditions and cancer research[1][2].
PRICE 208
DESCRIPTION 1. N-trans-Feruloyltyramine (Feruloyltyramine)(NTF) has hepatoprotective effect. 2. NTF has antioxidative activity against A??(1-42)-induced neuronal death. 3. NTF is likely to inhibit COX enzymes, thereby suppressing P-selectin expression on platelets, is a platelet aggregation inhibitor. 4. NTF inhibits melanogenesis in a dose-dependent manner, NTF induces downregulation of tyrosinase resulted in suppression of melanin biosynthesis in murine B16 melanoma cells.
DESCRIPTION 1. N-trans-Feruloyltyramine (Feruloyltyramine)(NTF) has hepatoprotective effect. 2. NTF has antioxidative activity against Aβ(1-42)-induced neuronal death. 3. NTF is likely to inhibit COX enzymes, thereby suppressing P-selectin expression on platelets, is a platelet aggregation inhibitor. 4. NTF inhibits melanogenesis in a dose-dependent manner, NTF induces downregulation of tyrosinase resulted in suppression of melanin biosynthesis in murine B16 melanoma cells. (TargetMol Bioactive Compound Library)
Cell lines
4
Organisms
1
Compound Sets
4
Cayman Chemical Bioactives
27459
MedChem Express Bioactive Compound Library
HY-N2410
Selleckchem Bioactive Compound Library
n-trans-feruloyltyramine
TargetMol Bioactive Compound Library
T3S0645
External IDs
26
Properties
(calculated by RDKit )
Molecular Weight
313.13
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
3
Rotatable Bonds
6
Ring Count
2
Aromatic Ring Count
2
cLogP
2.48
TPSA
78.79
Fraction CSP3
0.17
Chiral centers
0.0
Largest ring
6.0
QED
0.72
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
COX
Apoptosis
Reactive Oxygen Species (ROS)
Apoptosis, antioxidant, anti-inflammation
Reactive Oxygen Species
Pathway
Immunology/Inflammation
Neuroscience
Metabolic Enzyme/Protease
NF-κB
NF-¦ÊB
Source data