General
Preferred name
PITTSBURGH COMPOUND B UNLABELLED
Synonyms
Pittsburgh Compound-B ()
6-OH-BTA-1 ()
2-(4-(methylamino)phenyl)benzo[d]thiazol-6-ol ()
Pittsburgh compound B ()
PiB ()
(11c)-6-oh-bta-1 ()
(11c)pib ()
PIB C-11 ()
Pittsburgh compound b c-11 ()
P&D ID
PD119809
CAS
566170-04-5
566169-93-5
Tags
available
drug candidate
Drug indication
Alcohol dependence
Discovery agent
Drug Status
investigational
Max Phase
2.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Pittsburgh Compound B (PiB) is a PET tracer for A¦Â deposition in Alzheimer's disease (AD), with high affinity and specificity. Through click chemistry modification (introducing a PEG3 linker and an alkyne group at the 6-hydroxy position of Pittsburgh Compound B to generate a clickable Pittsburgh Compound B derivative, followed by covalent conjugation with azide-labeled fluorescent dyes or affinity tags via copper-catalyzed azide-alkyne cycloaddition (CuAAC)), Pittsburgh Compound B and its conjugates can be used for fluorescence imaging, ultrastructural studies, and the enrichment and characterization of A¦Â complexes. Pittsburgh Compound B holds great potential in Alzheimer's disease research[1].
PRICE
43
DESCRIPTION
PiB (Pittsburgh Compound-B) is a standard for analysis of 11C-PiB. 11C-PiB is a ??-amyloid PET imaging tracer for Alzheimer's disease diagnosis.
DESCRIPTION
PiB (Pittsburgh Compound-B) is a standard for analysis of 11C-PiB. 11C-PiB is a β-amyloid PET imaging tracer for Alzheimer's disease diagnosis.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
6
ChEMBL Drugs
DrugBank
DrugMAP
MedChem Express Bioactive Compound Library
TargetMol Bioactive Compound Library
ZINC Tool Compounds
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
27
Molecular Weight
256.07
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
2
Ring Count
3
Aromatic Ring Count
3
cLogP
3.71
TPSA
45.15
Fraction CSP3
0.07
Chiral centers
0.0
Largest ring
6.0
QED
0.73
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Amyloid-β
Amyloid-¦Â
Pathway
Neuronal Signaling
Source data
