General
Preferred name
FOLITIXORIN
Synonyms
Modufolin ()
5,10-Methylenetetrafolate ()
ANX-510 (free acid) ()
ANX-510 ()
FOLITIXORIN CALCIUM ()
Folitixorine ()
Folitixorina ()
COFACTOR ()
P&D ID
PD118764
CAS
3432-99-3
Tags
available
drug candidate
Drug Status
investigational
Max Phase
3.0
Drug indication
rectum cancer
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION ANX-510 is a folate-based biomodulator with potential antineoplastic activity. 5,10-methylenetetrahydrofolate (MTHF) stabilizes the covalent binding of the fluorouracil metabolite 5-5-fluoro-2'-deoxyuridine-5'-O-monophosphate (FdUMP) to its target enzyme, thymidylate synthase, which results in inhibition of thymidylate synthase, depletion of thymidine triphosphate (TTP), a necessary constituent of DNA, and tumor cell death. (BOC Sciences Bioactive Compounds)
Compound Sets
6
BOC Sciences Bioactive Compounds
anx-510-cas-3432-99-3-item-84-179302
Cayman Chemical Bioactives
33967
ChEMBL Drugs
CHEMBL117348
CHEMBL2103811
DrugBank
DB17113
MedChem Express Bioactive Compound Library
HY-14769
ReFrame library
External IDs
38
Properties
(calculated by RDKit )
Molecular Weight
457.17
Hydrogen Bond Acceptors
9
Hydrogen Bond Donors
6
Rotatable Bonds
7
Ring Count
4
Aromatic Ring Count
2
cLogP
-0.52
TPSA
193.98
Fraction CSP3
0.35
Chiral centers
2.0
Largest ring
6.0
QED
0.31
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Endogenous Metabolite
Pathway
Metabolic Enzyme/Protease
Solubility
Soluble in DMSO (Slightly), Methanol (Slightly, Sonicated)
Source data