General
Preferred name
Garcinone C
Synonyms
P&D ID
PD117971
CAS
76996-27-5
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Garcinone C, a xanthone derivative, is a natural compound extracted from Garcinia oblongifolia that is used as an anti-inflammatory, astringency and granulation-promoting medicine, and has potential cytotoxic effects on certain cancers. Garcinone C stimulates the expression levels of ATR and 4E-BP1, arrests the cell cycle, inhibits cell viability of the human Nasopharyngeal carcinoma (NPC) cell lines CNE1, CNE2, HK1 and HONE1 in a time? and dose?dependent manner through inhibition of Hedgehog signaling pathway. Garcinone C is orally active[1][2].
PRICE 750
DESCRIPTION Garcinone C is a xanthone derivative extracted from Garcinia oblongifolia Champ with anti-inflammatory, astringency, and granulation-promoting activities. Garcinone C is an AChE inhibitor and has potential cytotoxic effects on certain cancers. (TargetMol Bioactive Compound Library)
Compound Sets
3
MedChem Express Bioactive Compound Library
HY-N6954
Selleckchem Bioactive Compound Library
garcinone-c
TargetMol Bioactive Compound Library
TN1673
External IDs
15
Properties
(calculated by RDKit )
Molecular Weight
414.17
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
5
Rotatable Bonds
5
Ring Count
3
Aromatic Ring Count
3
cLogP
3.98
TPSA
131.36
Fraction CSP3
0.35
Chiral centers
0.0
Largest ring
6.0
QED
0.24
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
AChR
Antifection
ATR
STAT3
CDK7
ATM/ATR
CDK
Hedgehog
STAT
ATM/ATR, STAT, CDK
Pathway
Cell Cycle/Checkpoint
DNA Damage/DNA Repair
JAK/STAT Signaling
Microbiology/virology
Neuroscience
PI3K/Akt/mTOR signaling
Stem Cells
Cell Cycle/DNA Damage
PI3K/Akt/mTOR
Stem Cell/Wnt
Source data