General
Preferred name
OD36
Synonyms
OD-36 ()
OD 36 ()
OD 36 hydrochloride ()
RIPK2 Inhibitor OD36 (hydrochloride) ()
P&D ID
PD117733
CAS
1638644-62-8
2387510-88-3
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION OD36-induced inhibition of RIPK2 produces anti-inflammatory activity in animal models of inflammatory bowel conditions . (GtoPdb)
DESCRIPTION OD36 is a RIPK2 inhibitor with an IC50 of 5.3 nM. OD36 is a macrocyclic inhibitor with potent binding to the ALK2 kinase ATP pocket. OD36 shows ALK2-directed activity with KDs of 37 nM[1][2].
PRICE 190
DESCRIPTION MBD2 (Methyl-CpG-binding domain protein 2) inhibitor (Tocris Bioactive Compound Library)
DESCRIPTION OD-36, a macrocycle compound, has been found to be a RIPK2 inhibitor that could decrease cellular infiltration induced by MDP in neutrophils and lymphocytes. IC50: 5.3nM. (BOC Sciences Bioactive Compounds)
DESCRIPTION OD36 is a selective and potent RIPK2 inhibitor with an IC50 of 5.3 nM.OD36 inhibits ALK2 signaling and osteogenic differentiation (KD: 37 nM), and binds efficiently to the ALK2 kinase ATP pocket. (TargetMol Bioactive Compound Library)
Compound Sets
8
BOC Sciences Bioactive Compounds
od-36-cas-1638644-62-8-item-475924
Cayman Chemical Bioactives
42171
EUbOPEN Chemogenomics Library
EUB0002102
Guide to Pharmacology
10406
MedChem Express Bioactive Compound Library
HY-19628
Selleckchem Bioactive Compound Library
od36
TargetMol Bioactive Compound Library
T35694
Tocris Bioactive Compound Library
6598
External IDs
17
Properties
(calculated by RDKit )
Molecular Weight
330.09
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
1
Rotatable Bonds
0
Ring Count
4
Aromatic Ring Count
3
cLogP
2.87
TPSA
60.68
Fraction CSP3
0.25
Chiral centers
0.0
Largest ring
14.0
QED
0.69
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Angiogenesis
Apoptosis
NF-κB
Tyrosine Kinase/Adaptors
TGF-beta/Smad
Primary Target
Receptor Interacting Protein Kinases
MOA
Inhibitor
Target
RIP Kinase
TGF-β Receptor
TGF-¦Â Receptor
RIPK2
ALK2
Recommended Cell Concentration
1 uM
Source data