General
Preferred name
RESOKAEMPFEROL
Synonyms
5-Deoxykampferol ()
3,7,4'-Trihydroxyflavone ()
P&D ID
PD117619
CAS
2034-65-3
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION 3,7,4'-Trihydroxyflavone (5-Deoxykampferol) is a flavonoid compound that can be isolated from the stems of Rhus javanica var. roxburghiana. 3,7,4'-Trihydroxyflavone has the effect of cleaving DNA in the presence of copper ions. 3,7,4'-Trihydroxyflavone also has anti-inflammatory and antioxidant activities and can scavenge various reactive oxygen species (ROS) and reactive nitrogen species (RNS)[1][2].
PRICE 161
DESCRIPTION 3,7,4'-Trihydroxyflavone(5-Deoxykampferol) is a DNA-breaking flavonoid isolated from rosewood heartwood. It inhibits osteoclast differentiation, actin ring formation, and bone resorption in RAW 264.7 cells and bone marrow macrophages induced by NF-??B ligand (RANKL) receptor activators.
DESCRIPTION 3,7,4'-Trihydroxyflavone(5-Deoxykampferol) is a DNA-breaking flavonoid isolated from rosewood heartwood. It inhibits osteoclast differentiation, actin ring formation, and bone resorption in RAW 264.7 cells and bone marrow macrophages induced by NF-κB ligand (RANKL) receptor activators. (TargetMol Bioactive Compound Library)
Cell lines
1
Organisms
1
Compound Sets
2
MedChem Express Bioactive Compound Library
HY-111806
TargetMol Bioactive Compound Library
TN2143
External IDs
25
Properties
(calculated by RDKit )
Molecular Weight
270.05
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
3
Rotatable Bonds
1
Ring Count
3
Aromatic Ring Count
3
cLogP
2.58
TPSA
90.9
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.63
Structural alerts
2
aggregator (Aggregator Advisor)
Aggregators
aggregator (ZINC)
Aggregators
Custom attributes
(extracted from source data)
Target
DNA
Reactive Oxygen Species
DNA/RNA Synthesis
Leukotriene Receptor
Reactive Oxygen Species (ROS)
Pathway
Cell Cycle/DNA Damage
GPCR/G protein
Immunology/Inflammation
Metabolic Enzyme/Protease
NF-κB
DNA Damage/DNA Repair
NF-¦ÊB
Source data