General
Preferred name
LC3-mHTT-IN-AN2
Synonyms
5,7-Dihydroxy-4-phenylcoumarin ()
CL-271149 ()
AN2 ()
P&D ID
PD115689
CAS
7758-73-8
Tags
available
obsolete probe
PROTAC
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION LC3-mHTT-IN-AN2 (Compound AN2) is a mHTT-LC3 linker compound, which interacts with both mutant huntingtin protein (mHTT) and LC3B but not with wtHTT or irrelevant control proteins. LC3-mHTT-IN-AN2 reduces the levels of mHTT in an allele-selective manner in cultured Huntington disease (HD) mouse neurons[1].
PRICE 29
DESCRIPTION LC3-mHTT-IN-AN2 (5,7-Dihydroxy-4-phenylcoumarin) is found in the plant Passiflora serratodigitata with the antibacterial activity. (TargetMol Bioactive Compound Library)
Cell lines
0
Organisms
1
Compound Sets
5
MedChem Express Bioactive Compound Library
HY-130259
Obsolete Compounds
an2
Selleckchem Bioactive Compound Library
5-7-dihydroxy-4-phenylcoumarin
Selleckchem Bioactive Compound Library (Provided by Pfizer)
TargetMol Bioactive Compound Library
T5070
External IDs
19
Properties
(calculated by RDKit )
Molecular Weight
254.06
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
1
Ring Count
3
Aromatic Ring Count
3
cLogP
2.87
TPSA
70.67
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.65
Structural alerts
1
historic compounds (Chemical Probes.org)
Obsolete
Custom attributes
(extracted from source data)
Pathway
Autophagy
Microbiology/virology
MOA
Antibacterial
Target
Atg8/LC3
ATTECs
Source data