General
Preferred name
GSK-2239633
Synonyms
GSK 2239633A ()
GSK2239633A ()
P&D ID
PD103390
CAS
1240516-71-5
Tags
available
drug candidate
Drug indication
Asthma
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION GSK2239633A is a arylsulfonamide class CC-chemokine receptor 4 (CCR4) antagonist. It binds the intracellular domain of the receptor, and therefore has an allosteric mode of action . (GtoPdb)
DESCRIPTION Potent and selective GPR84 agonist (Tocris Bioactive Compound Library)
Compound Sets
6
Drug Repurposing Hub
DrugMAP
DMUNVXR
Guide to Pharmacology
10416
MedChem Express Bioactive Compound Library
HY-100183
ReFrame library
Tocris Bioactive Compound Library
7071
External IDs
13
Properties
(calculated by RDKit )
Molecular Weight
548.1
Hydrogen Bond Acceptors
8
Hydrogen Bond Donors
3
Rotatable Bonds
9
Ring Count
4
Aromatic Ring Count
4
cLogP
4.0
TPSA
122.55
Fraction CSP3
0.25
Chiral centers
0.0
Largest ring
6.0
QED
0.29
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Primary Target
Chemokine CC Receptors
MOA
Antagonist
CC chemokine receptor antagonist
Pathway
GPCR/G protein
Immunology/Inflammation
Target
CCR
Source data