General
Preferred name
Nevanimibe
Synonyms
ATR-101 ()
PD-132301 hydrochloride ()
ATR101 hydrochloride ()
Nevanimibe HCl ()
Nevanimibe hydrochloride ()
Atr-101 ()
PD-132301-02 ()
PD-132301-2 ()
PD-132301 HYDROCHLORIDE ()
PD132301-02 ()
PD132301-2 ()
ATR-101 HYDROCHLORIDE ()
PD 132301-02 ()
ATR-101 FREE BASE ()
PD-132301 ()
Nevanimiba ()
PD 132301 ()
P&D ID
PD103173
CAS
133825-81-7
133825-80-6
Tags
available
drug candidate
Drug indication
Arteriosclerosis
Cushing syndrome
Malignant adrenal gland cancer
Drug Status
investigational
Max Phase
2.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Nevanimibe hydrochloride (PD-132301 hydrochloride) is an orally active and selective acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1) inhibitor with an EC50 of 9 nM. Nevanimibe hydrochloride inhibits ACAT2 with an EC50 of 368 nM. Nevanimibe hydrochloride induces cell apoptosis and has the potential for adrenocortical cancer[1].
PRICE 282
DESCRIPTION Nevanimibe hydrochloride (PD-132301 hydrochloride) is an orally active, selective inhibitor of acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1) with an EC50 of 9 nM. (TargetMol Bioactive Compound Library)
Compound Sets
10
Axon Medchem Screening Library
2960
ChEMBL Drugs
CHEMBL542103
CHEMBL46423
DrugBank
DB16254
DrugMAP
DMUMVXK
EU-OPENSCREEN Bioactive Compound Library
EOS100062
Mcule NIBR MoA Box Subset
MCULE-6751118506
MedChem Express Bioactive Compound Library
HY-100399A
Novartis Chemogenetic Library (NIBR MoA Box)
ReFrame library
TargetMol Bioactive Compound Library
T12225L
External IDs
31
Properties
(calculated by RDKit )
Molecular Weight
421.31
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
2
Rotatable Bonds
7
Ring Count
3
Aromatic Ring Count
2
cLogP
6.63
TPSA
44.37
Fraction CSP3
0.52
Chiral centers
0.0
Largest ring
6.0
QED
0.53
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Acyltransferase
ACAT-1
Apoptosis
ACAT inhibitor
Pathway
Metabolic Enzyme/Protease
Metabolism
Member status
member
MOA
SOAT-2 inhibitor
Source data