General
Preferred name
SORAPRAZAN
Synonyms
BYK61359 ()
BYK 61359 ()
P&D ID
PD103166
CAS
261944-46-1
Tags
available
drug candidate
Drug indication
Peptic ulcer
Drug Status
investigational
Max Phase
2.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Soraprazan (BYK61359) is a selective, reversible K-competitive inhibitor of the H,K-ATPase (Ki=6.4 nM), with an IC50 of 0.19 ¦ÌM in gastric glands. Soraprazan binds to the H,K-ATPase with a Kd of 28.27 nM. Soraprazan shows immediate inhibition of acid secretion and is more than 2000-fold selective for H,K-ATPase over Na,K- and Ca-ATPases[1].
PRICE 593
DESCRIPTION Soraprazan (BYK61359) is a selective potassium channel inhibitor that inhibits gastric acid secretion and ameliorates age-related eye disease by removing lipofuscin from retinal pigment epithelial (RPE) cells. (TargetMol Bioactive Compound Library)
Compound Sets
7
ChEMBL Drugs
CHEMBL2105502
Drug Repurposing Hub
DrugBank
DB17856
DrugMAP
DMCS8FM
MedChem Express Bioactive Compound Library
HY-100414
ReFrame library
TargetMol Bioactive Compound Library
T12977
External IDs
15
Properties
(calculated by RDKit )
Molecular Weight
367.19
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
2
Rotatable Bonds
5
Ring Count
4
Aromatic Ring Count
3
cLogP
3.18
TPSA
68.02
Fraction CSP3
0.38
Chiral centers
3.0
Largest ring
6.0
QED
0.68
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
Sodium Channel
Proton Pump
MOA
Proton Pump inhibitor
Pathway
Membrane Transporter/Ion Channel
Source data