General
Preferred name
SP-13786
Synonyms
UAMC-1110 ()
P&D ID
PD103126
CAS
1448440-52-5
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION UAMC-1110 is a highly potent and selective inhibitor of fibroblast activation protein (FAP) with an IC50 of 3.2 nM. UAMC-1110 also inhibits prolyl oligopeptidase (PREP) with an IC50 of 1.8 ¦ÌM[1].
PRICE 214
DESCRIPTION SP-13786 is an inhibitor of fibroblast activation protein (FAP) and prolyl oligopeptidase (PREP) with IC50 values ??of 3.2 nM and 1.8 ??M, respectively.
DESCRIPTION SP-13786 is an inhibitor of fibroblast activation protein (FAP) and prolyl oligopeptidase (PREP) with IC50 values ​​of 3.2 nM and 1.8 μM, respectively. (TargetMol Bioactive Compound Library)
Compound Sets
5
Cayman Chemical Bioactives
41857
CZ-OPENSCREEN Bioactive Library
MedChem Express Bioactive Compound Library
HY-100684
Selleckchem Bioactive Compound Library
sp-13786
TargetMol Bioactive Compound Library
T7890
External IDs
11
Properties
(calculated by RDKit )
Molecular Weight
344.11
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
3
Ring Count
3
Aromatic Ring Count
2
cLogP
1.72
TPSA
86.09
Fraction CSP3
0.29
Chiral centers
1.0
Largest ring
6.0
QED
0.92
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
FAP
PREP
Prolyl Endopeptidase (PREP)
Pathway
Immunology/Inflammation
Metabolic Enzyme/Protease
Source data