General
Preferred name
CB-1158
Synonyms
CB-1158 dihydrochloride ()
INCB01158 dihydrochloride ()
CB-1158 dihydrochloride ( free base) ()
CB1158 dihydrochloride ()
INCB 01158 dihydrochloride ()
CB-1158 Hydrochloride ()
INCB01158 Hydrochloride ()
NUMIDARGISTAT ()
Numidargistat (dihydrochloride) ()
INCB01158 ()
CB-1158 (dihydrochloride) ()
INCB01158 (dihydrochloride) ()
Numidargistat dihydrochloride ()
Incb001158 ()
Arginase inhibitor incb001158 ()
Incb 001158 ()
INCB-001158 ()
P&D ID
PD102950
CAS
2095732-06-0
Tags
available
drug candidate
Drug Status
investigational
Max Phase
2.0
Drug indication
Neoplasm
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Numidargistat (CB-1158) dihydrochloride is a potent and orally active inhibitor of arginase, with IC50s of 86 nM and 296 nM for recombinant human arginase 1 and recombinant human arginase 2, respectively. Immuno-oncology agent[1].
PRICE
284
DESCRIPTION
Numidargistat dihydrochloride (CB-1158 dihydrochloride) is an orally active and highly effective arginase (ARG1) inhibitor, an immuno-oncology agent that inhibits TGF-??2-induced subcapsular cataract by reducing the proliferation of lens epithelial cells (LEC) and decreasing the expression of fibronectin, ??-SMA, collagen 1A1, and vimentin.
DESCRIPTION
Numidargistat (CB-1158) is a potent and orally active inhibitor of arginase, with IC50s of 86 nM and 296 nM for recombinant human arginase 1 and recombinant human arginase 2, respectively. Immuno-oncology agent[1].
DESCRIPTION
Numidargistat dihydrochloride (CB-1158 dihydrochloride) is an orally active and highly effective arginase (ARG1) inhibitor, an immuno-oncology agent that inhibits TGF-β2-induced subcapsular cataract by reducing the proliferation of lens epithelial cells (LEC) and decreasing the expression of fibronectin, α-SMA, collagen 1A1, and vimentin.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
5
ChEMBL Drugs
DrugBank
EUbOPEN Chemogenomics Library
MedChem Express Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
20
Molecular Weight
287.17
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
5
Rotatable Bonds
6
Ring Count
1
Aromatic Ring Count
0
cLogP
-2.17
TPSA
150.11
Fraction CSP3
0.82
Chiral centers
3.0
Largest ring
5.0
QED
0.35
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Arginase-1
Arginase
Pathway
Immunology/Inflammation
Metabolic Enzyme/Protease
Recommended Cell Concentration
1 uM
Source data
