General
Preferred name
JNJ-64619178
Synonyms
ONAMETOSTAT ()
JNJ64619178 ()
P&D ID
PD102914
CAS
2086772-26-9
Tags
available
drug candidate
Drug indication
Solid tumour/cancer
Myelodysplastic syndrome
Drug Status
investigational
Max Phase
1.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Onametostat (JNJ-64619178) is a selective, orally active and pseudo-irreversible protein arginine methyltransferase 5 (PRMT5) inhibitor with an IC50 of 0.14 nM. Onametostat has potent activity in lung cancer[1][2].
PRICE 281
DESCRIPTION Onametostat (JNJ-64619178) is a small molecule inhibitor of protein arginine methyltransferase 5 (PRMT5) . It was developed for anti-tumour potential. Onametostat occupies the S-adenosylmethionine and substrate pockets of PRMT5 and traps the enzyme (in complex with its cofactor MEP50; WDR77) in a catalytically inactive conformation. The compound has a very slow off-rate. (GtoPdb)
DESCRIPTION JNJ-64619178 is a selective PRMT5 inhibitor with potent in vitro and in vivo activity. JNJ-64619178 binds simultaneously to the SAM- and protein substrate- binding pockets of the PRMT5/MEP50 complex with a pseudo-irreversible mode-of-action. It can be developed as the treatment of some malignancies. (BOC Sciences Bioactive Compounds)
DESCRIPTION JNJ-64619178 is a selective, orally active, and pseudo-irreversible inhibitor of protein arginine methyltransferase 5 (IC50: 0.14 nM). It has effective activity In lung cancer. (TargetMol Bioactive Compound Library)
Cell lines
1
Organisms
0
Compound Sets
10
AdooQ Bioactive Compound Library
A16861
BOC Sciences Bioactive Compounds
jnj-64619178-cas-2086772-26-9-291446
Cayman Chemical Bioactives
29231
ChEMBL Drugs
CHEMBL4249337
Drug Repurposing Hub
DrugMAP
DMDBW2N
EUbOPEN Chemogenomics Library
EUB0002261
Guide to Pharmacology
11749
MedChem Express Bioactive Compound Library
HY-101564
TargetMol Bioactive Compound Library
T15624
External IDs
15
Properties
(calculated by RDKit )
Molecular Weight
482.11
Hydrogen Bond Acceptors
8
Hydrogen Bond Donors
4
Rotatable Bonds
4
Ring Count
5
Aromatic Ring Count
4
cLogP
2.82
TPSA
136.1
Fraction CSP3
0.32
Chiral centers
4.0
Largest ring
6.0
QED
0.35
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
Histone methyltransferase
PRMT5
MOA
protein arginine N-methyltransferase inhibitor
Pathway
Epigenetics
Chromatin/Epigenetic
Recommended Cell Concentration
None
Source data