General
Preferred name
linperlisib
Synonyms
YY-20394 ()
PI3K¦Ä-IN-2 ()
PI3K??-IN-2 ()
PI3K??IN-2 ()
PI3Kδ-IN-2 ()
PI3Kδ-IN-2 ()
P&D ID
PD102679
CAS
1702816-75-8
Tags
available
drug candidate
Drug Status
investigational
Max Phase
1.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Linperlisib (YY-20394) is a PI3Kδ inhibitor claimed by Shanghai Yingli Pharmaceutical Company in their patent US20160244432A1 (as compound 10) . (GtoPdb)
DESCRIPTION PI3Kδ-IN-2 is a potent and selective inhibitor ofPI3Kδ (IC50= 6.4 M). (BOC Sciences Bioactive Compounds)
Compound Sets
10
BOC Sciences Bioactive Compounds
pi3k-in-2-cas-1702816-75-8-item-7402
ChEMBL Drugs
CHEMBL4574601
Drug Repurposing Hub
DrugBank
DB17235
EU-OPENSCREEN Bioactive Compound Library
EOS100111
Guide to Pharmacology
10466
MedChem Express Bioactive Compound Library
HY-102031
PKIDB
ReFrame library
TargetMol Bioactive Compound Library
T6330
External IDs
12
Properties
(calculated by RDKit )
Molecular Weight
588.25
Hydrogen Bond Acceptors
10
Hydrogen Bond Donors
2
Rotatable Bonds
8
Ring Count
5
Aromatic Ring Count
3
cLogP
3.03
TPSA
130.01
Fraction CSP3
0.54
Chiral centers
0.0
Largest ring
6.0
QED
0.41
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Pathway
PI3K/Akt/mTOR signaling
PI3K/Akt/mTOR
Target
PI3K??
PI3K
MOA
PI3K inhibitor
Solubility
DMSO: 10 mM
Source data