General
Preferred name
GNE-493
Synonyms
P&D ID
PD102636
CAS
1033735-94-2
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION GNE-493 is a potent, selective, and orally available dual pan-PI3K/mTOR inhibitor with IC50s of 3.4/12/16/16/32 nM for PI3Kα/PI3Kβ/PI3Kγ/PI3Kδ/mTOR respectively. (BOC Sciences Bioactive Compounds)
Cell lines
1
Organisms
0
Compound Sets
5
BOC Sciences Bioactive Compounds
gne-493-cas-1033735-94-2-item-84-456565
Cayman Chemical Bioactives
29224
MedChem Express Bioactive Compound Library
HY-10811
Selleckchem Bioactive Compound Library
gne-493
TargetMol Bioactive Compound Library
T7166
External IDs
12
Properties
(calculated by RDKit )
Molecular Weight
372.14
Hydrogen Bond Acceptors
9
Hydrogen Bond Donors
2
Rotatable Bonds
3
Ring Count
4
Aromatic Ring Count
3
cLogP
1.79
TPSA
110.28
Fraction CSP3
0.41
Chiral centers
0.0
Largest ring
6.0
QED
0.72
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Pathway
PI3K/Akt/mTOR
Target
MTOR
PI3K
mTOR,PI3K
Source data