General
Preferred name
N-guanyl-1,7-diaminoheptane
Synonyms
N1-guanyl-1,7-diaminoheptane ()
GC7 Sulfate ()
N1-guanyl-1,7-diaminoheptane Sulfate ()
GC7 (sulfate) ()
P&D ID
PD102633
CAS
150333-69-0
150417-90-6
Tags
available
drug candidate
Drug indication
Discovery agent
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
50
DESCRIPTION
GC7 Sulfate is a potent inhibitor of deoxyhypusine synthase (DHS). Eukaryotic translation initiation factor 5A2 (eIF5A2) is the only known substrate for DHS, so GC7 inhibits the activation of eIF5A2 by inhibiting DHS activity.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
3
Organisms
0
Compound Sets
6
Cayman Chemical Bioactives
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
25
Molecular Weight
172.17
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
4
Rotatable Bonds
7
Ring Count
0
Aromatic Ring Count
0
cLogP
0.38
TPSA
87.92
Fraction CSP3
0.88
Chiral centers
0.0
Largest ring
0.0
QED
0.25
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Member status
member
MOA
DHPS inhibitor
Pathway
Autophagy
Cell Cycle/DNA Damage
Target
DNA/RNA Synthesis,eIF,p21
DNA/RNA Synthesis
DHPS
Source data
