General
Preferred name
LSZ-102
Synonyms
LSZ102 ()
(2E)-3-[4-({2-[2-(1,1-difluoroethyl)-4-fluorophenyl]-6-hydroxy-1-benzothiophen-3-yl}oxy)phenyl]prop-2-enoic acid ()
P&D ID
PD102331
CAS
2135600-76-7
Tags
available
drug candidate
Drug Status
investigational
Max Phase
1.0
Drug indication
Breast cancer
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION LSZ-102 is a potent, orally bioavailable, selective estrogen receptor degrader (SERD) with an IC50 value of 0.2 nM.
PRICE 303
DESCRIPTION LSZ-102 is an effective and selective degrader of estrogen receptor (IC50 = 0.2 nM) and can be used in studies about ER?? positive breast cancer.
DESCRIPTION LSZ102 is a potent and orally bioavailable selective estrogen receptor degrader (SERD) . It was developed for as a potential treatment for ERα positive breast cancer. (GtoPdb)
DESCRIPTION LSZ-102 is an effective and selective degrader of estrogen receptor (IC50 = 0.2 nM) and can be used in studies about ERα positive breast cancer. (TargetMol Bioactive Compound Library)
Cell lines
1
Organisms
0
Compound Sets
8
Cayman Chemical Bioactives
41834
ChEMBL Drugs
CHEMBL4076124
Drug Repurposing Hub
DrugBank
DB15362
Guide to Pharmacology
12145
MedChem Express Bioactive Compound Library
HY-111486
ReFrame library
TargetMol Bioactive Compound Library
T15788
External IDs
13
Properties
(calculated by RDKit )
Molecular Weight
470.08
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
6
Ring Count
4
Aromatic Ring Count
4
cLogP
7.41
TPSA
66.76
Fraction CSP3
0.08
Chiral centers
0.0
Largest ring
6.0
QED
0.29
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
estrogen receptor
Estrogen Receptor/ERR
MOA
Selective Estrogen Receptor Modulator (SERM)
Pathway
Vitamin D Related/Nuclear Receptor
Endocrinology/Hormones
Source data