General
Preferred name
RO-6870810
Synonyms
RO6870810 ()
RO 6870810 ()
TEN-010 ()
TEN010 ()
(S)-JQ-35 ()
RG6146, Ro-6870810, (S)-JQ-35 ()
TEN-010 (RG6146,Ro-6870810,(S)-JQ-35) ()
BET INHIBITOR TEN-010 ()
Rg 6146 ()
(S)-JQ35 ()
Jq-35, (s)- ()
Bet inhibitor ro6870810 ()
P&D ID
PD102188
CAS
1349719-98-7
Tags
available
drug candidate
Drug indication
Multiple myeloma
Myelodysplastic syndrome
Drug Status
investigational
Max Phase
1.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
(S)-JQ-35 (TEN-010) is an inhibitor of the Bromodomain and Extra-Terminal (BET) family bromodomain-containing proteins with potential antineoplastic activity.
PRICE
208
DESCRIPTION
TEN-010 (RO6870810) is a BET inhibitor . Structurally it is an analogue of , with optimised chemical and biological properties. Development of TEN-010 was progressed by Roche, who acquired the originating biotech firm Tensha Therapeutics. Tensha claimed several bromodomain inhibitors in patent WO2016069578 .
BET inhibitors bind to the bromodomains of the bromodomain and extra-terminal motif (BET) proteins BRD2, BRD3, BRD4, and BRDT. This mechanism acts to prevent protein-protein interaction between BET proteins and acetylated histones and transcription factors. The action disrupts chromatin remodeling and inhibits expression of some growth-promoting genes which slows proliferation in susceptible tumours. (GtoPdb)
BET inhibitors bind to the bromodomains of the bromodomain and extra-terminal motif (BET) proteins BRD2, BRD3, BRD4, and BRDT. This mechanism acts to prevent protein-protein interaction between BET proteins and acetylated histones and transcription factors. The action disrupts chromatin remodeling and inhibits expression of some growth-promoting genes which slows proliferation in susceptible tumours. (GtoPdb)
DESCRIPTION
(S)-JQ-35 (TEN-010) is a BET bromodomain inhibitor with anti-tumor activity, particularly in breast cancer research.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
9
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
15
Molecular Weight
539.22
Hydrogen Bond Acceptors
8
Hydrogen Bond Donors
1
Rotatable Bonds
7
Ring Count
5
Aromatic Ring Count
3
cLogP
3.94
TPSA
78.65
Fraction CSP3
0.48
Chiral centers
1.0
Largest ring
7.0
QED
0.46
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Apoptosis
Epigenetic Reader Domain
BET
MOA
Bromodomain inhibitor
Pathway
Epigenetics
Chromatin/Epigenetic
Source data
