General
Preferred name
PD101480
Synonyms
360A (iodide) ()
360 A iodide ()
360A ()
360A iodide ()
P&D ID
PD101480
CAS
737763-37-0
794458-56-3
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE 313
DESCRIPTION 360A is a 2,6-pyridine-dicarboxamide derivative displaying strong affinity and selectivity for G-quadruplex structures and selective telomerase inhibition in vitro assays. It is a G-quadruplex ligand, which can influence the consequence of G-quadruplex formation and/or stabilization. (BOC Sciences Bioactive Compounds)
DESCRIPTION 360A is a strong affinity and selectivity inhibitor of G-quadruplex structures. (BOC Sciences Bioactive Compounds)
DESCRIPTION 360A is a stabilizing G-Quadruplex ligand, and also inhibits telomerase activity for telomerase in TRAP-G4 assay(IC50 : 300 nM). (TargetMol Bioactive Compound Library)
Cell lines
3
Organisms
0
Compound Sets
3
BOC Sciences Bioactive Compounds
360a-iodide-cas-737763-37-0-item-84-463319
360a-cas-794458-56-3-item-84-463331
MedChem Express Bioactive Compound Library
HY-15595A
TargetMol Bioactive Compound Library
T7409
External IDs
17
Properties
(calculated by RDKit )
Molecular Weight
449.18
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
2
Rotatable Bonds
4
Ring Count
5
Aromatic Ring Count
5
cLogP
3.54
TPSA
78.85
Fraction CSP3
0.07
Chiral centers
0.0
Largest ring
6.0
QED
0.41
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Cell Cycle/DNA Damage
Cell Cycle/Checkpoint
DNA Damage/DNA Repair
Target
G-quadruplex
Telomerase
Source data