General
Preferred name
A-385358
Synonyms
P&D ID
PD101427
CAS
406228-55-5
Tags
available
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
A-385358 is a selective inhibitor of Bcl-XL with Kis of 0.80 and 67 nM for Bcl-XL and Bcl-2, respectively.
PRICE
199
DESCRIPTION
A-385358 is a selective Bcl-xL inhibitor with Kis of 0.80 nM for Bcl-xL and 67 nM for Bcl-2, respectively.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
1
Organisms
0
Compound Sets
4
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
10
Molecular Weight
639.25
Hydrogen Bond Acceptors
9
Hydrogen Bond Donors
2
Rotatable Bonds
13
Ring Count
4
Aromatic Ring Count
3
cLogP
5.86
TPSA
124.89
Fraction CSP3
0.41
Chiral centers
1.0
Largest ring
6.0
QED
0.13
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Bcl-xL
Bcl-2
Bcl-2 Family
Pathway
Apoptosis
Source data
