General
Preferred name
SAR-125844
Synonyms
SAR125884 hydrochlorid (1116743-46-4(free base)) ()
SAR125884 ()
SAR125844 ()
SAR 125844 ()
P&D ID
PD101312
CAS
1116743-46-4
Tags
available
drug candidate
Drug indication
Solid tumour/cancer
Drug Status
investigational
Max Phase
2.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION SAR125844 is inhibitor of the proto-oncogene c-Met (also known as hepatocyte growth factor receptor [HGFR]) with potential antineoplastic activity. Upon intravenous administration, c-Met inhibitor SAR125844 binds to c-Met, thereby disrupting c-Met-mediated signal transduction pathways. This may result in cell growth inhibition in tumors that overexpress c-Met. c-Met, a receptor tyrosine kinase overexpressed or mutated in a variety of cancers, plays an important role in tumor cell proliferation, survival, invasion, metastasis and tumor angiogenesis. (BOC Sciences Bioactive Compounds)
Cell lines
1
Organisms
0
Compound Sets
9
BOC Sciences Bioactive Compounds
sar125844-cas-1116743-46-4-item-84-462780
Cayman Chemical Bioactives
37542
ChEMBL Drugs
CHEMBL4461070
DrugBank
DB15382
DrugMAP
DMJ34G6
MedChem Express Bioactive Compound Library
HY-16446
ReFrame library
Selleckchem Bioactive Compound Library
sar125844
TargetMol Bioactive Compound Library
T5677
External IDs
18
Properties
(calculated by RDKit )
Molecular Weight
550.14
Hydrogen Bond Acceptors
10
Hydrogen Bond Donors
2
Rotatable Bonds
7
Ring Count
6
Aromatic Ring Count
5
cLogP
4.15
TPSA
109.57
Fraction CSP3
0.24
Chiral centers
0.0
Largest ring
6.0
QED
0.31
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Tyrosine Kinase/Adaptors
"Protein Tyrosine Kinase/RTK
Apoptosis
MAPK/ERK Pathway
PI3K/Akt/mTOR
Protein Tyrosine Kinase/RTK
Target
MET RTK
Akt
c-Met/HGFR
MEK
PI3K
c-Met
Solubility
Soluble in DMSO
Source data