General
Preferred name
AMG-009
Synonyms
AMG 009 ()
P&D ID
PD101014
CAS
1027847-67-1
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION AMG-009 is a potent antagonist of prostaglandin D2, with IC50 of 3 nM and 12 nM for CRTH2 and DP receptors, respectively.
PRICE 142
DESCRIPTION AMG-009 is an orally active, small molecule dual D prostanoid(DP) receptor and chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) antagonist. It was in preclinical development for the treatment of asthma and allergic rhinitis. It was developed by Amgen Inc. (BOC Sciences Bioactive Compounds)
DESCRIPTION AMG-009 is a selective and potent dual antagonist of CRTH2 and DP, with an IC50 value of 3 nM for CRTH2 and 12 nM for DP receptors. (TargetMol Bioactive Compound Library)
Compound Sets
5
BOC Sciences Bioactive Compounds
amg-009-cas-1027847-67-1-item-474980
Cayman Chemical Bioactives
42392
MedChem Express Bioactive Compound Library
HY-19499
ReFrame library
TargetMol Bioactive Compound Library
T14211
External IDs
13
Properties
(calculated by RDKit )
Molecular Weight
580.08
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
3
Rotatable Bonds
12
Ring Count
3
Aromatic Ring Count
3
cLogP
5.75
TPSA
131.03
Fraction CSP3
0.23
Chiral centers
0.0
Largest ring
6.0
QED
0.23
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
CRTH2
DP
Prostaglandin Receptor
Pathway
Endocrinology/Hormones
GPCR/G protein
Immunology/Inflammation
Solubility
10 mM in DMSO
Source data