General
Preferred name
Pimobendan hydrochloride
Synonyms
UD-CG115 (hydrochloride) ()
Pimobendan (hydrochloride) ()
P&D ID
PD100749
CAS
77469-98-8
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Pimobendan is a selective inhibitor of PDE3 (cGMP-specific 3',5'-cGMP phosphodiesterase 3). (Enamine Bioactive Compounds)
DESCRIPTION Pimobendan hydrochloride is a selective inhibitor of PDE3. It exhibits selective inhibition of PDE III isolated from guinea pig cardiac muscle with IC50 of 0.32 uM compared to the inhibition of PDE I and PDE II (IC50s >30 μM). It shows a beneficial effect on survival in the murine model of EMC virus-induced myocarditis. It also significantly reduces myocardial cellular infiltration, the level of intracardiac tumor necrosis factor (TNF)-α and interleukin (IL)-1β compared with the control group, which shows no effect on myocardial necrosis, heart weight and body weight. It suppresses expression of the intracardiac iNOS gene , causing reduction of intracardiac NO production. (BOC Sciences Bioactive Compounds)
Compound Sets
3
BOC Sciences Bioactive Compounds
pimobendan-hydrochloride-cas-77469-98-8-item-84-463326
Enamine Bioactive Compounds
EBC-130024
Enamine BioReference Compounds
External IDs
16
Properties
(calculated by RDKit )
Molecular Weight
370.12
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
3
Ring Count
4
Aromatic Ring Count
3
cLogP
3.52
TPSA
79.37
Fraction CSP3
0.21
Chiral centers
1.0
Largest ring
6.0
QED
0.74
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Phosphodiesterase (PDE)
Pathway
Metabolic Enzyme/Protease
Source data