General
Preferred name
Bavachalcone
Synonyms
BROUSSOCHALCONE B ()
P&D ID
PD100444
CAS
28448-85-3
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Bavachalcone is a potent inducer of apoptosis. Bavachalcone exerts anticancer activity by promoting autophagy and apoptosis in HepG2 cells. Bavachalcone acts as an anti-neuroinflammatory and antidepressant through the NF-¦ÊB pathway. Bavachalcone inhibits osteoclasts by interfering with ERK and Akt signaling pathways and the expression of c-Fos and NFATc1. Bavachalcone exhibits a significant inhibitory effect on baculovirus-expressed BACE-1 in vitro[1][2][3][4].
PRICE 147
DESCRIPTION Bavachalcone inhibited osteoclast formation from precursor cells with the IC(50) of approximately 1.5 microg ml(-1). The activation of MEK, ERK, and Akt by receptor activator of nuclear factor kappaB ligand (RANKL), the osteoclast differentiation factor, was prominently reduced in the presence of bavachalcone. The induction of c-Fos and NFATc1, key transcription factors for osteoclastogenesis, by RANKL was also suppressed by bavachalcone. Bavachalcone exhibited a significant inhibitory effect on baculovirus-expressed BACE-1 in vitro. Bavachalcone had stronger inhibition on UGT1A1 and UGT1A7 than corylin which did not inhibit UGT1A1, UGT1A3, UGT1A7, UGT1A8, UGT1A10, and UGT2B4. Data fitting using Dixon and Lineweaver-Burk plots demonstrated the noncompetitive inhibition of bavachalcone against UGT1A1 and UGT1A7-mediated 4-MU glucuronidation reaction. The values of inhibition kinetic parameters (Ki) were 5.41 μ M and 4.51μ M for UGT1A1 and UGT1A7, respectively. (BOC Sciences Bioactive Compounds)
DESCRIPTION Bavachalcone, a major bioactive compound isolated from *Psoralea corylifolia* L., may serve as a therapeutic drug for bone resorption-associated diseases. It protects endothelial function by increasing AMPK activity and MnSOD expression while reducing mitochondrial oxidative stress. (TargetMol Bioactive Compound Library)
Cell lines
2
Organisms
0
Compound Sets
5
BOC Sciences Bioactive Compounds
bavachalcone-cas-28448-85-3-item-84-463614
Cayman Chemical Bioactives
34673
MedChem Express Bioactive Compound Library
HY-N0231
Selleckchem Bioactive Compound Library
bavachalcone
TargetMol Bioactive Compound Library
T3S0137
External IDs
23
Properties
(calculated by RDKit )
Molecular Weight
324.14
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
3
Rotatable Bonds
5
Ring Count
2
Aromatic Ring Count
2
cLogP
4.21
TPSA
77.76
Fraction CSP3
0.15
Chiral centers
0.0
Largest ring
6.0
QED
0.44
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
Akt
antibiotic
Apoptosis
Autophagy
Bacterial
NF-κB
PERK
¦Á-glucosidase, UGT1A1, UGT1A7
Pathway
Microbiology/virology
Anti-infection
Cell Cycle/DNA Damage
PI3K/Akt/mTOR
NF-¦ÊB
Source data