General
Preferred name
LMP-744
Synonyms
NSC706744 hydrochloride ()
MJ-III65 hydrochloride ()
LMP744 (HCl) ()
LMP744 ()
NSC-706744 ()
LMP744 (hydrochloride) ()
MJ-III65 ()
NSC706744 ()
MJ-III65 (hydrochloride) ()
NSC706744 (hydrochloride) ()
LMP744 hydrochloride ()
NSC-706743 ()
MJ-III-65 ()
Topoisomerase-1 inhibitor lmp744 ()
Lmp744 ()
P&D ID
PD099773
CAS
308246-52-8
308246-57-3
Tags
available
drug candidate
nuisance
Drug indication
Lymphoma
Solid tumour/cancer
Drug Status
investigational
Max Phase
1.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
LMP744 hydrochloride (MJ-III65 hydrochloride) is a DNA intercalator and Topoisomerase I (Top1) inhibitor with antitumor activity[1].
PRICE
366
DESCRIPTION
LMP744 hydrochloride (NSC-706744 hydrochloride) is a DNA intercalator and Topoisomerase I (Top1) inhibitor with antitumor activity.?
DESCRIPTION
LMP744 hydrochloride (NSC-706744 hydrochloride) is a DNA intercalator and Topoisomerase I (Top1) inhibitor with antitumor activity.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
8
Organisms
0
Compound Sets
7
ChEMBL Drugs
DrugMAP
EU-OPENSCREEN Bioactive Compound Library
MedChem Express Bioactive Compound Library
Nuisance compounds in cellular assays
ReFrame library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
31
Molecular Weight
452.16
Hydrogen Bond Acceptors
9
Hydrogen Bond Donors
2
Rotatable Bonds
8
Ring Count
5
Aromatic Ring Count
3
cLogP
1.93
TPSA
108.25
Fraction CSP3
0.33
Chiral centers
0.0
Largest ring
6.0
QED
0.39
Structural alerts
2
keto_phenone_A(11)
c:1:c-3:c(:c:c:c:1)-[#6]:2:[#7]:[!#1]:[#6]:[#6]:[#6]:2-[#6]-3=[#8]
PAINS Family C
Intercalation
Nuisance compounds
Related compounds
Custom attributes
(extracted from source data)
Target
Topo I
Topoisomerase
Pathway
DNA Damage/DNA Repair
Cell Cycle/DNA Damage
Source data
