General
Preferred name
narasin
Synonyms
Narasin (sodium salt) ()
Narasina ()
Narasine ()
Salinomycin, 4-methyl-, (4s)- ()
Antibiotic a-28086 factor a ()
Compound 79891 ()
Monteban ()
C-7819B ()
COMPD-79891 ()
Narasin a ()
P&D ID
PD098389
CAS
55134-13-9
58331-17-2
Tags
available
drug
Approved by
FDA
Drug Status
vet_approved
approved
experimental
investigational
Max Phase
2.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Narasin is an anti-protozoal agent with activity against Coccidia parasites (e.g. Toxoplasma gondii). It also has limited antibacterial activity against Gram +ve bacteria. (GtoPdb)
DESCRIPTION Narasin is a cationic ionophore antibiotic and coccidiostat agent. Narasin inhibits NF-¦ÊB signaling and induces tumor cells apoptosis. Narasin has antimicrobial, antiviral anticancer activity. Narasin inhibits tumor metastasis and growth of ER¦Á?positive breast cancer cells by inactivation of the TGF-¦Â/SMAD3 and IL?6/STAT3 signaling pathways[1][2][3].
Cell lines
0
Organisms
1
Compound Sets
8
Cayman Chemical Bioactives
19447
ChEMBL Drugs
CHEMBL2104423
DrugBank
DB11432
DrugBank Approved Drugs
DB11432
DrugCentral
5583
Guide to Pharmacology
10835
MedChem Express Bioactive Compound Library
HY-121410
ReFrame library
External IDs
28
Properties
(calculated by RDKit )
Molecular Weight
764.51
Hydrogen Bond Acceptors
10
Hydrogen Bond Donors
4
Rotatable Bonds
12
Ring Count
5
Aromatic Ring Count
0
cLogP
6.43
TPSA
161.21
Fraction CSP3
0.91
Chiral centers
19.0
Largest ring
6.0
QED
0.16
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
antibiotic
Apoptosis
Bacterial
NF-κB
Parasite
Pathway
Anti-infection
NF-¦ÊB
Source data