General
Preferred name
GDC-0575
Synonyms
ARRY-575 ()
RG7741 ()
GDC 0575 ()
ARRY575 ()
GDC0575 ()
GDC-0575 (ARRY-575, RG7741) ()
GDC-0575 (dihydrochloride) ()
ARRY-575 (dihydrochloride) ()
RG7741 (dihydrochloride) ()
GDC-0575 (ARRY-575) ()
GDC0575 monohydrochloride ()
P&D ID
PD098309
CAS
1196541-47-5
1657014-42-0
1196504-54-7
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION GDC-0575 (ARRY-575, RG7741) is a highly-selective oral small-molecule Chk1 inhibitor with an IC50 of 1.2 nM.
PRICE 157
DESCRIPTION GDC-0575 dihydrochloride (ARRY-575 dihydrochloride) is an orally bioavailable CHK1 inhibitor, with an IC50 of 1.2 nM, and has antitumor activity.
PRICE 98
DESCRIPTION GDC0575 monohydrochloride (ARRY575) is a potent and selective inhibitor of cell cycle checkpoint kinase 1 (Chk1) with an IC50 of 1.2?nM. GDC-0575 specifically binds to and inhibits Chk1; this may result in tumor cells bypassing Chk1-dependent cell cycle arrest in the S and G2/M phases, which permits the cells to undergo DNA repair prior to entry into mitosis.
DESCRIPTION GDC-0575 is a highly-selective, potent and oral small-molecule Chk1 inhibitor (IC50 = 1.2 nM). (BOC Sciences Bioactive Compounds)
DESCRIPTION GDC-0575 (ARRY-575) is a highly-selective oral small-molecule Chk1 inhibitor(IC50 of 1.2 nM). (TargetMol Bioactive Compound Library)
DESCRIPTION GDC0575 monohydrochloride (ARRY575) is a potent and selective inhibitor of cell cycle checkpoint kinase 1 (Chk1) with an IC50 of 1.2 nM. GDC-0575 specifically binds to and inhibits Chk1; this may result in tumor cells bypassing Chk1-dependent cell cycle arrest in the S and G2/M phases, which permits the cells to undergo DNA repair prior to entry into mitosis. (TargetMol Bioactive Compound Library)
Compound Sets
9
AdooQ Bioactive Compound Library
A16811
BOC Sciences Bioactive Compounds
gdc-0575-cas-1196541-47-5-334091
Cayman Chemical Bioactives
34300
Drug Repurposing Hub
MedChem Express Bioactive Compound Library
HY-112167
HY-112167A
Other bioactive compounds
ReFrame library
Selleckchem Bioactive Compound Library
gdc-0575
TargetMol Bioactive Compound Library
T7300
T27407
External IDs
22
Properties
(calculated by RDKit )
Molecular Weight
377.09
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
3
Rotatable Bonds
3
Ring Count
4
Aromatic Ring Count
2
cLogP
2.6
TPSA
87.04
Fraction CSP3
0.5
Chiral centers
1.0
Largest ring
6.0
QED
0.77
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Checkpoint Kinase (Chk)
CHK1
Chk
MOA
Chk inhibitor
Pathway
Cell Cycle/DNA Damage
Cell Cycle/Checkpoint
Solubility
DMSO: 75 mg/mL
Ehanol: 5 mg/mL
Source data