General
Preferred name
EX229
Synonyms
Compound 991 ()
C991 ()
ex229 (compound 991) ()
EX-229 ()
P&D ID
PD098305
CAS
1219739-36-2
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION EX229, a Benzimidazole derivative, is a potent and allosteric activator of AMP-activated protein kinase (AMPK), with Kds of 0.06 ¦ÌM, 0.06 ¦ÌM and 0.51 ¦ÌM for ¦Á1¦Â1¦Ã1, ¦Á2¦Â1¦Ã1 and ¦Á1¦Â2¦Ã1 in biolayer interferometry, respectively.
PRICE 100
DESCRIPTION EX229 (C991) is an allosteric activator of AMPK, with Kds of 0.06 ??M, 0.06 ??M and 0.51 ??M for ??1??1??1, ??2??1??1, and ??1??2??1, respectively.
DESCRIPTION EX229 (compound 991), also known as AMPK Activator 991, is a potent AMPK activator that displays 5-10-fold more potent than A769662 in activating AMPK. (BOC Sciences Bioactive Compounds)
DESCRIPTION EX229 (C991) is an allosteric activator of AMPK, with Kds of 0.06 μM, 0.06 μM and 0.51 μM for α1β1γ1, α2β1γ1, and α1β2γ1, respectively. (TargetMol Bioactive Compound Library)
Compound Sets
11
AdooQ Bioactive Compound Library
A16795
BOC Sciences Bioactive Compounds
ex229-cas-1219739-36-2-334119
Cayman Chemical Bioactives
34690
CZ-OPENSCREEN Bioactive Library
EU-OPENSCREEN Bioactive Compound Library
EOS100454
Guide to Pharmacology
14098
Mcule NIBR MoA Box Subset
MCULE-1156300744
MedChem Express Bioactive Compound Library
HY-112769
Novartis Chemogenetic Library (NIBR MoA Box)
Selleckchem Bioactive Compound Library
ex229-compound-991
TargetMol Bioactive Compound Library
TQ0028
External IDs
16
Properties
(calculated by RDKit )
Molecular Weight
431.1
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
4
Ring Count
5
Aromatic Ring Count
5
cLogP
6.17
TPSA
80.14
Fraction CSP3
0.08
Chiral centers
0.0
Largest ring
6.0
QED
0.36
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
AMPK
Member status
member
MOA
AMPK allosteric activator
Pathway
Chromatin/Epigenetic
PI3K/Akt/mTOR signaling
Epigenetics
PI3K/Akt/mTOR
Solubility
DMSO: 12 mg/mL
Source data